Monoclonal Antibody Production
Monoclonal antibodies (mAb) are used extensively ш basic biomedical research, in diagnosis of disease, and in treatment of illnesses, such as infections and cancer. Antibodies are important tools used by many investigators in their research and have led to many medical advances.Producing mAb requires immunizing an animal, usually a mouse: obtaining immune cells from its spleen; and fusing the cells with a cancer cell (such as cells from a myeloma) to make them immortal, which means that they will grow and divide indefinitely. A tumor of the fused cells is called a hybridorna. and these cells secrete mAb. The development of the immortal hybridoma requires the use of animals; no commonly accepted nonanimal alternatives are available.
類別:
年:
1999
出版商:
National Academy Press
語言:
english
頁數:
60
ISBN 10:
0309064473
ISBN 13:
9780309064477
文件:
PDF, 585 KB
IPFS:
,
english, 1999
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